CXCL6
Description
The CXCL6 (C-X-C motif chemokine ligand 6) is a protein-coding gene located on chromosome 4.
CXCL6, also known as Granulocyte chemotactic protein 2 (GCP-2), is a small cytokine belonging to the CXC chemokine family. CXCL6 attracts neutrophils by interacting with the chemokine receptors CXCR1 and CXCR2. The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.
CXCL6 attracts neutrophil granulocytes to sites of inflammation and infection by binding to and activating its receptors, CXCR1 and CXCR2. It also promotes angiogenesis (blood vessel formation) and has potent antibacterial activity against both Gram-positive and Gram-negative bacteria, exhibiting 90 times stronger activity compared to CXCL5 and CXCL7.
CXCL6 is also known as CKA-3, GCP-2, GCP2, SCYB6.
