CXCL3
Description
The CXCL3 (C-X-C motif chemokine ligand 3) is a protein-coding gene located on chromosome 4.
CXCL3 is a small cytokine belonging to the CXC chemokine family, also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg), and macrophage inflammatory protein-2-beta (MIP2b). It controls migration and adhesion of monocytes and mediates its effects on target cells by interacting with the CXCR2 chemokine receptor. CXCL3 also regulates the migration of cerebellar granule neuron precursors towards the internal layers of the cerebellum during cerebellar morphogenesis. Reduced CXCL3 expression leads to increased medulloblastoma frequency, as the precursor cells remain at the cerebellar surface, proliferate under Sonic hedgehog stimulation, and become targets for transforming insults. Treatment with CXCL3 prevents medulloblastoma growth in a Shh-type mouse model. CXCL3 is a target for medulloblastoma therapy. CXCL3 is directly regulated transcriptionally by BTG2. The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.
CXCL3 is also known as CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3.
