CTNND2 : catenin delta 2
Description
The CTNND2 (catenin delta 2) is a protein-coding gene located on chromosome 5.
The CTNND2 gene provides instructions for making a protein called delta-catenin. This protein is active in the nervous system, where it likely helps cells stick together (cell adhesion) and plays a role in cell movement. In the developing brain, it may help guide nerve cells to their proper positions as part of a process known as neuronal migration. In mature nerve cells, delta-catenin is located in specialized outgrowths called dendrites. Dendrites branch out from the cell and receive information from nearby nerve cells. This information is relayed across synapses, which are junctions between nerve cells where cell-to-cell communication occurs. Delta-catenin appears to play a crucial role in the function of synapses.
Delta-catenin plays a key role in neuronal development, particularly in the formation and maintenance of dendritic spines and synapses. It participates in regulating Wnt signaling, potentially affecting beta-catenin turnover by promoting its interaction with GSK3B, leading to phosphorylation, ubiquitination, and degradation. When bound to ZBTB33, it acts as a transcriptional activator. Additionally, it may contribute to neuronal cell adhesion and tissue morphogenesis by influencing adhesion molecules.
CTNND2 is also known as GT24, NPRAP.
