CTBP1
Description
The CTBP1 (C-terminal binding protein 1) is a protein-coding gene located on chromosome 4.
CtBP1 (C-terminal-binding protein 1) is a protein encoded by the CTBP1 gene in humans. It is one of two CtBP proteins, the other being CtBP2. CtBP1 was initially identified as a protein that binds to a specific motif in the C-terminus of adenovirus E1A proteins. Both CtBP1 and CtBP2 function as transcriptional corepressors, meaning they bind to DNA-binding proteins and help to turn off gene expression. They do this by recruiting enzymes that modify histones, adding repressive marks and removing activating marks. CtBP proteins can also interact with each other, potentially bringing together gene regulatory complexes. CtBP1 is widely expressed throughout development and in adults, while CtBP2 has a more restricted pattern of expression. CtBP proteins have multiple roles in the body and appear to be particularly important in regulating the transition from epithelial to mesenchymal cells, as well as influencing metabolism. They sense the balance of NADH and NAD+ in cells, which is important for energy production.
CtBP1 is a corepressor protein that interacts with a variety of transcription regulators, such as GLIS2 and BCL6. It has dehydrogenase activity and is involved in regulating the balance between tubular and stacked structures in the Golgi complex. CtBP1 plays a role in brown adipose tissue (BAT) differentiation.
CTBP1 is also known as BARS, HADDTS.
