CSTF1
Description
The CSTF1 (cleavage stimulation factor subunit 1) is a protein-coding gene located on chromosome 20.
The CSTF1 gene encodes the 50 kDa subunit of the cleavage stimulation factor (CSTF), a protein complex involved in the polyadenylation and 3' end cleavage of pre-mRNAs. This protein contains transducin-like repeats, similar to mammalian G protein beta subunits. Multiple transcript variants of this gene have been found, all encoding the same protein but with different 5' UTRs. CSTF1 interacts with BARD1.
CSTF1 plays a critical role in the polyadenylation and 3'-end cleavage of mammalian pre-mRNAs, a crucial step in mRNA processing. It is believed to facilitate the interaction of CSTF with other factors, forming a stable complex on the pre-mRNA, which is essential for these processes.
CSTF1 is also known as CstF-50, CstFp50.
