CSF2
Description
The CSF2 (colony stimulating factor 2) is a protein-coding gene located on chromosome 5.
CSF2, also known as Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), is a cytokine produced by various cells like macrophages, T cells, mast cells, natural killer cells, endothelial cells, and fibroblasts. It stimulates the production of white blood cells, primarily granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes mature into macrophages and dendritic cells in tissues. CSF2 plays a critical role in the immune response, particularly in fighting infections by increasing the number of macrophages. It also affects mature immune cells, such as enhancing neutrophil migration and altering cell surface receptors. CSF2 signals through the STAT5 pathway. Pharmaceutical analogs of natural CSF2 include sargramostim and molgramostim.
CSF2 is a cytokine that promotes the growth and differentiation of hematopoietic precursor cells, including granulocytes, macrophages, eosinophils, and erythrocytes.
CSF2 is also known as CSF, GMCSF.
