CSAD

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Description

The CSAD (cysteine sulfinic acid decarboxylase) is a protein-coding gene located on chromosome 12.

CSAD catalyzes the removal of a carboxyl group (CO2) from several amino acids: L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate. This process produces beta-alanine, hypotaurine, and taurine, respectively. CSAD has a strong preference for 3-sulfino-L-alanine as a substrate. However, it does not demonstrate any activity towards glutamate.

CSAD is also known as CSD, PCAP.

Associated Diseases

• Parkinson disease
• lysosomal storage disease
• Alzheimer disease
• multiple sclerosis
• type 1 diabetes mellitus
• hypertension, pregnancy-induced
• toxemia of pregnancy
• familial primary pulmonary hypoplasia
• pyknoachondrogenesis
• type 2 diabetes mellitus