CRYGC
Description
The CRYGC (crystallin gamma C) is a protein-coding gene located on chromosome 2.
CRYGC, or crystallin, gamma C, is a protein encoded by the CRYGC gene. Crystallins are divided into two classes: taxon-specific, or enzyme, and ubiquitous. The ubiquitous class, which includes CRYGC, is responsible for maintaining the transparency and refractive index of the vertebrate eye lens. These proteins are highly stable and are made and retained throughout life, as lens central fiber cells lose their nuclei during development. Mammalian lens crystallins are categorized into alpha, beta, and gamma families, with beta and gamma crystallins forming a superfamily. Alpha and beta families are further subdivided into acidic and basic groups. Crystallins share seven protein regions: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins, like CRYGC, are a homogenous group of highly symmetrical, monomeric proteins that typically lack connecting peptides and terminal extensions. They undergo differential regulation after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are clustered together in a genomic segment.
CRYGC is also known as CCL, CRYG3, CTRCT2.
