CRTC3

Description

The CRTC3 (CREB regulated transcription coactivator 3) is a protein-coding gene located on chromosome 15.

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene. This gene has been shown to be linked to weight gain.

CRTC3 acts as a transcriptional coactivator for CREB1, activating transcription through both consensus and variant cAMP response element (CRE) sites. It functions as a coactivator in the SIK/TORC signaling pathway, being active when dephosphorylated. It operates independently of CREB1 'Ser-133' phosphorylation and enhances the interaction of CREB1 with TAF4. CRTC3 regulates the expression of specific CREB-activated genes, such as the steroidogenic gene, StAR. It is a potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Additionally, it acts as a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

CRTC3 is also known as TORC-3, TORC3.

Associated Diseases

WES Whole Exome Sequencing