CRTC2

Description

The CRTC2 (CREB regulated transcription coactivator 2) is a protein-coding gene located on chromosome 1.

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene. CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP. CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC). CRTC2 has been shown to interact with SNF1LK2 and YWHAQ.

CRTC2 acts as a coactivator for CREB1, enhancing transcription through both standard and alternative cAMP response elements (CREs). It participates in the SIK/TORC signaling pathway, becoming active when dephosphorylated, independent of CREB1 Ser-133 phosphorylation. CRTC2 strengthens the interaction between CREB1 and TAF4. It plays a role in gluconeogenesis within the LKB1/AMPK/TORC2 signaling pathway. CRTC2 regulates the expression of specific genes, including the steroidogenic gene StAR. In muscle cells, it acts as a potent coactivator of PPARGC1A and promotes mitochondrial biogenesis. Additionally, CRTC2 serves as a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

CRTC2 is also known as TORC-2, TORC2.

Associated Diseases

WES Whole Exome Sequencing