CRTC1

Description

The CRTC1 (CREB regulated transcription coactivator 1) is a protein-coding gene located on chromosome 19.

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene. It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands and various regions of the adult central nervous system.

== Clinical significance == Production of CRTC1 is blocked in Alzheimer's disease.

== See also == Transcription coregulator

== References ==

== Further reading ==

== External links == CRTC1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CRTC1 genome location and CRTC1 gene details page in the UCSC Genome Browser. This article incorporates text from the United States National Library of Medicine, which is in the public domain.

CRTC1 acts as a coactivator for CREB1, enhancing transcription through both canonical and non-canonical cAMP response elements (CREs). It participates in the SIK/TORC signaling pathway, exhibiting activity when dephosphorylated, independent of CREB1 phosphorylation at Ser-133. CRTC1 strengthens the interaction between CREB1 and TAF4, influencing the expression of CREB-regulated genes, including the steroidogenic gene, StAR. In muscle cells, CRTC1 acts as a potent coactivator of PGC1alpha, promoting mitochondrial biogenesis. Within the hippocampus, CRTC1 contributes to the maintenance of late-phase long-term potentiation (L-LTP) at Schaffer collateral-CA1 synapses. It may play a role in dendritic growth during cortical neuron development. CRTC1, in collaboration with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light signals, it coactivates CREB-mediated transcription of PER1, a crucial component of the photic entrainment of the circadian clock.

CRTC1 is also known as MAML2, MECT1, Mam-2, TORC-1, TORC1, WAMTP1.

Associated Diseases

WES Whole Exome Sequencing