CRHR2
CRHR2: A Key Player in Stress and Beyond
Description:
CRHR2 (corticotropin-releasing hormone receptor 2) is a G protein-coupled receptor that binds to corticotropin-releasing hormone (CRH), a potent neuropeptide involved in the stress response. CRHR2 is widely expressed throughout the brain and body, including in the hypothalamus, pituitary gland, and immune system.
Associated Diseases:
Dysregulation of CRHR2 has been implicated in various diseases and disorders, including:
- Mood disorders: CRHR2 is overexpressed in patients with depression and anxiety, suggesting a role in the altered stress responses observed in these conditions.
- Post-traumatic stress disorder (PTSD): PTSD is associated with increased CRHR2 expression and activity, contributing to the heightened anxiety and stress response characteristic of this disorder.
- Addiction: CRHR2 plays a role in the development and maintenance of addiction, as it is involved in the reinforcing effects of drugs of abuse.
- Inflammatory diseases: CRHR2 is expressed on immune cells and is involved in regulating the inflammatory response. Dysregulation of CRHR2 can contribute to chronic inflammation and autoimmune disorders.
Did you Know ?
In individuals with PTSD, CRHR2 expression in the amygdala (a brain region involved in fear and anxiety) is significantly increased. This suggests that heightened CRHR2 activity may underlie the exaggerated stress response observed in PTSD.
