CREB3

Description

The CREB3 (cAMP responsive element binding protein 3) is a protein-coding gene located on chromosome 9.

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.

== Interactions == CREB3 has been shown to interact with Host cell factor C1.

== See also == CREB

== References ==

== Further reading ==

== External links == CREB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CREB3 genome location and CREB3 gene details page in the UCSC Genome Browser. This article incorporates text from the United States National Library of Medicine, which is in the public domain.

CREB3 is an endoplasmic reticulum (ER)-bound transcription factor that directly binds to DNA and activates gene expression. It plays a critical role in the unfolded protein response (UPR), promoting cell survival in response to ER stress. CREB3 is also involved in cell proliferation, migration, differentiation, tumor suppression, and inflammatory gene expression. It positively regulates the chemotaxis of leukocytes by acting on LKN-1/CCL15-induced signaling. CREB3 associates with chromatin at the HERPUD1 promoter and induces the transcriptional activation of chemokine receptors.

CREB3 is also known as LUMAN, LZIP, sLZIP.

Associated Diseases

WES Whole Exome Sequencing