CREB1
Description
The CREB1 (cAMP responsive element binding protein 1) is a protein-coding gene located on chromosome 2.
CREB1, also known as CREB-1, is a protein encoded by the CREB1 gene in humans. It binds to the cAMP response element, a DNA sequence found in many viral and cellular promoters, stimulating transcription. CREB1 is a member of the leucine zipper family of DNA-binding proteins and binds as a homodimer to the cAMP-responsive element, an octameric palindrome. It is phosphorylated by several protein kinases and induces gene transcription in response to hormonal stimulation of the cAMP pathway. Alternate splicing of the CREB1 gene produces two transcript variants encoding different isoforms. CREB1 interacts with several proteins, including CEBPB, CREB binding protein, FHL2, FHL3, FHL5, HTATIP, P53, and RPS6KA5.
CREB1 is a phosphorylation-dependent transcription factor that activates gene expression by binding to the cAMP response element (CRE), a DNA sequence found in many viral and cellular promoters. The TORC coactivators enhance transcription activation independently of Ser-119 phosphorylation. CREB1 plays a role in various cellular processes, including the synchronization of circadian rhythmicity and the differentiation of adipose cells. It also regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling.
CREB1 is also known as CREB, CREB-1.
