CRB3
Description
The CRB3 (crumbs cell polarity complex component 3) is a protein-coding gene located on chromosome 19.
CRB3 is a human gene that encodes a protein belonging to the Crumbs family. This protein is involved in establishing cell polarity in epithelial cells and is associated with tight junctions at the apical surface of these cells. Several isoforms of this protein exist, arising from alternative splicing.
CRB3 is involved in establishing cell polarity in mammalian epithelial cells. It regulates the formation of tight junctions. CRB3 promotes phosphorylation and cytoplasmic retention of YAP1 and WWTR1/TAZ, which suppresses TGF-beta1-dependent transcription of genes like CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1, and SMAD7.
CRB3 is also known as -.
Associated Diseases
- endometrial cancer
- congenital tracheal stenosis
- nonpapillary renal cell carcinoma
- microvillus inclusion disease
- NPHP3-related Meckel-like syndrome
- Peutz-Jeghers syndrome
- mitochondrial complex 4 deficiency, nuclear type 19
- surfactant metabolism dysfunction, pulmonary, 1
- familial visceral myopathy
