CRABP2

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Description

The CRABP2 (cellular retinoic acid binding protein 2) is a protein-coding gene located on chromosome 1.

CRABP2 is a protein that binds to retinoic acid, a derivative of vitamin A. It is similar in structure to CRABP1 but has a lower affinity for retinoic acid. CRABP2 is found in cells that produce large amounts of retinoic acid and may help regulate the effects of retinoic acid in the cell. Its role is not fully understood, but it may be important in the growth, differentiation, and development of human skin. CRABP2 is involved in moving retinoic acid from the cytoplasm to the nucleus, where it binds to retinoic acid receptors and influences gene expression. CRABP2 is specifically found in tissues that also express RAR-β and cellular retinol binding protein 1, suggesting a coordinated role in regulating retinoic acid signaling.

CRABP2 facilitates the movement of retinoic acid into the nucleus. It acts as a gatekeeper, controlling the amount of retinoic acid that reaches the nuclear retinoic acid receptors, thereby influencing the regulation of gene expression.

CRABP2 is also known as CRABP-II, RBP6.

Associated Diseases

• postaxial polydactyly type A
• Oliver syndrome
• isolated congenital digital clubbing
• breast cancer
• syndactyly type 4
• extensor tendons of finger anomalies
• polydactyly of an index finger
• polydactyly of a biphalangeal thumb
• triphalangeal thumb-polysyndactyly syndrome
• polydactyly of a triphalangeal thumb
• ectrodactyly-polydactyly syndrome
• polysyndactyly 4
• hallux varus-preaxial polysyndactyly syndrome