CPTP
Description
The CPTP (ceramide-1-phosphate transfer protein) is a protein-coding gene located on chromosome 1.
CPTP may refer to:
CPTP mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. It is essential for maintaining the normal structure of the Golgi stacks. CPTP can bind to phosphoceramides with various aliphatic chains, but it prefers lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains. It is inefficient with phosphoceramides containing lignoceryl (C24:0). CPTP plays a role in regulating cellular levels of ceramide-1-phosphate, contributing to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. It does not have activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid, and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. CPTP regulates autophagy, inflammasome-mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis.
CPTP is also known as GLTPD1.
