CPSF7

Description

The CPSF7 (cleavage and polyadenylation specific factor 7) is a protein-coding gene located on chromosome 11.

Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the CPSF7 gene. CPSF7, also known as CFIm59, is the cleavage factor of two closely associated protein complexes in the 3' untranslated region of a newly synthesized pre-messenger RNA (mRNA) molecule used in gene transcription. CPSF7 is one of three Cleavage and polyadenylation specificity factors (CPSF), the other two being CFIm25 (or CPSF5/NUDT21) and CFIm68 (or CPSF6).

CPSF7 is a component of the Cleavage factor Im (CFIm) complex, which plays a crucial role in the maturation of pre-mRNA into functional mRNAs. The CFIm complex acts as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing, ensuring the proper formation of the 3' end of mRNA molecules. This complex contributes to the recruitment of multiprotein complexes to specific sequences on the pre-mRNA 3'-end, known as cleavage and polyadenylation signals (pA signals). The CFIm complex is a key regulator of cleavage and polyadenylation site choice during alternative cleavage and polyadenylation (APA), a process where pre-mRNAs can have variable 3'-end formation due to the presence of multiple pA signals. CFIm binds to 5'-UGUA-3' elements located in the 3'- untranslated region (UTR) of a large number of pre-mRNAs, directly activating the mRNA 3'-processing machinery. CPSF7 also binds to pA signals in RNA substrates.

CPSF7 is also known as CFIm59.

Associated Diseases

WES Whole Exome Sequencing