CPSF6
Description
The CPSF6 (cleavage and polyadenylation specific factor 6) is a protein-coding gene located on chromosome 12.
Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene.
== Function == The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.
== Interactions == CPSF6 has been shown to interact with WWP1 and PLSCR1. CPSF6 plays an important role in the nuclear import and integration of HIV-1 capsids.
== References ==
== External links == Human CPSF6 genome location and CPSF6 gene details page in the UCSC Genome Browser.
CPSF6 is a subunit of the cleavage factor Im (CFIm) complex, which plays a crucial role in the maturation of pre-mRNA into functional mRNA. This complex activates the pre-mRNA 3'-end cleavage and polyadenylation process. CFIm binds to specific sequences on the pre-mRNA 3'-end, known as cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, leading to alternative cleavage and polyadenylation (APA) and the production of mRNAs with variable 3'-end formation. The CFIm complex regulates the choice of cleavage and polyadenylation sites during APA by binding to 5'-UGUA-3' elements in the 3'-untranslated region (UTR) of a large number of pre-mRNAs. CPSF6 enhances the binding of NUDT21/CPSF5 to these 5'-UGUA-3' elements located upstream of pA signals and promotes RNA looping, directly activating the mRNA 3'-processing machinery. CPSF6 is also involved in mRNA export.
CPSF6 is also known as CFIM, CFIM68, CFIM72, HPBRII-4, HPBRII-7.
