CPSF1
Description
The CPSF1 (cleavage and polyadenylation specific factor 1) is a protein-coding gene located on chromosome 8.
CPSF1, encoded by the CPSF1 gene, is a protein involved in the processing of pre-messenger RNA (pre-mRNA) at its 3' end. This process occurs in two steps: first, site-specific cleavage by an endonuclease, followed by the addition of a poly(A) tail. CPSF1 is the largest component of the CPSF complex, which includes other subunits like CPSF2, CPSF3, CPSF4, FIP1L1, Symplekin, and WDR33. This complex, located in the nucleus, plays a crucial role in recognizing the cleavage site and recruiting other factors for polyadenylation.
CPSF1 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex, which is essential for the proper processing of pre-messenger RNA (pre-mRNA) at its 3' end. It recognizes the AAUAAA signal sequence, interacts with poly(A) polymerase and other factors, and facilitates cleavage and poly(A) addition to the pre-mRNA. This subunit plays a crucial role in the RNA recognition step of the polyadenylation reaction. Additionally, it may be involved in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain.
CPSF1 is also known as CPSF160, HSU37012, MYP27, P/cl.18.
