CPEB4
Description
The CPEB4 (cytoplasmic polyadenylation element binding protein 4) is a protein-coding gene located on chromosome 5.
CPEB4 is a sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. This binding induces a conformational change in CPEB4, similar to the Venus fly trap mechanism. CPEB4 regulates the activation of the unfolded protein response (UPR) in liver cells by maintaining translation of CPE-regulated mRNAs during conditions of inhibited global protein synthesis. It is also essential for cell cycle progression, particularly during cytokinesis and chromosomal segregation. CPEB4 acts as an oncogene, promoting tumor growth and progression by positively regulating the translation of t-plasminogen activator/PLAT. Additionally, it stimulates melanocyte proliferation. In contrast to CPEB1 and CPEB3, CPEB4 is not involved in synaptic plasticity, learning, or memory. CPEB4 interacts with TOB1.
CPEB4 is also known as CPE-BP4, hCPEB-4.
