COX7A2L
Description
The COX7A2L (cytochrome c oxidase subunit 7A2 like) is a protein-coding gene located on chromosome 2.
Cytochrome c oxidase subunit 7A-related protein, mitochondrial is an enzyme encoded by the COX7A2L gene in humans. It is part of cytochrome c oxidase (COX), the final component of the mitochondrial respiratory chain, which transfers electrons from reduced cytochrome c to oxygen. COX is a complex made up of 3 catalytic subunits encoded by mitochondrial genes and several structural subunits encoded by nuclear genes. The mitochondrial subunits are involved in electron transfer, while the nuclear-encoded subunits regulate and assemble the complex. The protein encoded by the COX7A2L gene is similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also shares similarity with the mouse Sig81 protein sequence. This gene is expressed in all tissues, and its expression is increased in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and is involved in the increased energy production in target cells by estrogen.
COX7A2L is also known as COX7AR, COX7RP, EB1, SCAF1, SCAFI, SIG81.
