CORO1C
Description
The CORO1C (coronin 1C) is a protein-coding gene located on chromosome 12.
Coronin-1C is a protein encoded by the CORO1C gene in humans. It belongs to the WD repeat protein family, which is involved in various cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WD repeats are conserved regions of approximately 40 amino acids, often involved in the formation of protein complexes.
CORO1C plays a crucial role in directed cell migration by regulating the activation and localization of RAC1, leading to increased levels of activated RAC1 at the leading edge of migrating cells. It is essential for the normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules, and vimentin intermediate filaments. CORO1C participates in endoplasmic reticulum-associated endosome fission by localizing to endosome membrane tubules and promoting recruitment of TMCC1. This recruitment facilitates the recruitment of the endoplasmic reticulum to endosome tubules, enabling fission. Endosome membrane fission of early and late endosomes is essential for separating regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. CORO1C is required for normal cell proliferation, cell migration, and the formation of lamellipodia. Additionally, it is essential for the normal distribution of mitochondria within cells.
CORO1C is also known as HCRNN4.
