COPZ1
Description
The COPZ1 (COPI coat complex subunit zeta 1) is a protein-coding gene located on chromosome 12.
COPZ1 (Coatomer subunit zeta-1) is a protein encoded by the COPZ1 gene in humans. It has been shown to interact with COPG. The gene location and details are available on the UCSC Genome Browser.
Coatomer is a protein complex that binds to dilysine motifs and interacts with Golgi non-clathrin-coated vesicles. This complex plays a crucial role in transporting proteins from the endoplasmic reticulum (ER) through the Golgi apparatus to the trans Golgi network. It is essential for budding from Golgi membranes and the retrograde transport of dilysine-tagged proteins back to the ER. The zeta subunit, also known as COPZ1, is involved in regulating coat assembly, which in turn affects the rate of protein transport due to its ability to associate and dissociate with the coatomer complex.
COPZ1 is also known as CGI-120, COPZ, HSPC181, zeta-COP, zeta1-COP.
