COPS7A
Description
The COPS7A (COP9 signalosome subunit 7A) is a protein-coding gene located on chromosome 12.
COP9 signalosome complex subunit 7a is a protein encoded by the COPS7A gene in humans. The CSN complex is a regulator of ubiquitin conjugation and is involved in various cellular and developmental processes. You can find more information about the COPS7A gene and its location on the UCSC Genome Browser.
The COP9 signalosome (CSN) complex is a key regulator of the ubiquitin (Ubl) conjugation pathway. It controls the activity of SCF-type E3 ligases by removing NEDD8 from their cullin subunits, decreasing their Ubl ligase activity. This process involves complexes like SCF, CSA, and DDB2. Additionally, the CSN complex is involved in phosphorylation of several proteins, including p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1, and IRF8/ICSBP. This phosphorylation is likely facilitated by interactions with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN regulates their degradation by the Ubl system, promoting the degradation of TP53 and protecting JUN from degradation.
COPS7A is also known as CSN7, CSN7A, SGN7a.
