COPG2
Description
The COPG2 (COPI coat complex subunit gamma 2) is a protein-coding gene located on chromosome 7.
Coatomer subunit gamma-2 is a protein encoded by the COPG2 gene in humans. It interacts with Dopamine receptor D1 and COPB1. The COPG2 gene is located on chromosome 12 and its details can be found in the UCSC Genome Browser.
The coatomer is a protein complex found in the cytoplasm that binds to dilysine motifs and associates with Golgi non-clathrin-coated vesicles. This complex plays a key role in transporting newly synthesized proteins from the endoplasmic reticulum (ER) through the Golgi apparatus to the trans Golgi network. It is essential for budding from Golgi membranes and the retrograde transport of dilysine-tagged proteins back to the ER. In mammals, the coatomer requires association with ADP-ribosylation factors (ARFs), small GTP-binding proteins, to be recruited to membranes. The coatomer also influences Golgi structure and the processing, activity, and endocytic recycling of LDL receptors.
COPG2 is also known as 2-COP, gamma-2-COP.
