COPG1
Description
The COPG1 (COPI coat complex subunit gamma 1) is a protein-coding gene located on chromosome 3.
COPG1 is a protein-coding gene. The protein encoded by this gene is a subunit of the coatomer complex, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles.
COPG1, also known as coatomer subunit gamma-1, is a component of the coatomer complex, a cytosolic protein complex crucial for intracellular protein trafficking. It binds to dilysine motifs and associates with Golgi non-clathrin-coated vesicles, mediating the transport of newly synthesized proteins from the endoplasmic reticulum (ER) through the Golgi apparatus to the trans Golgi network. The coatomer complex is essential for budding from Golgi membranes and retrograde transport of dilysine-tagged proteins back to the ER. In mammals, the coatomer requires ADP-ribosylation factors (ARFs) for membrane recruitment. Additionally, the coatomer plays a role in maintaining Golgi structural integrity, regulating LDL receptor processing and recycling, and controlling lipid storage. It contributes to lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 on the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface, facilitating lipolysis.
COPG1 is also known as COPG.
Associated Diseases
- Alzheimer disease
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- muscular dystrophy
- isolated agammaglobulinemia
