COPA
Description
The COPA (COPI coat complex subunit alpha) is a protein-coding gene located on chromosome 1.
COPA or COPA may refer to: Coatomer subunit alpha, also known as Alpha-coat protein, HEP-COP.
COPA, also known as coatomer subunit alpha, is a crucial component of the coatomer complex, a cytosolic protein assembly that plays a vital role in intracellular protein transport. The coatomer binds to dilysine motifs on proteins and reversibly associates with Golgi non-clathrin-coated vesicles, facilitating the movement of newly synthesized proteins from the endoplasmic reticulum (ER) through the Golgi apparatus to the trans Golgi network. This complex is essential for budding from Golgi membranes and for the retrograde transport of dilysine-tagged proteins back from the Golgi to the ER. In mammals, the coatomer requires association with ADP-ribosylation factors (ARFs), small GTP-binding proteins, for recruitment to membranes. Additionally, the coatomer complex influences the structural integrity of the Golgi apparatus and is involved in the processing, activity, and recycling of low-density lipoprotein (LDL) receptors.
COPA is also known as AILJK, HEP-COP, alpha-COP.
