COMMD1
Description
The COMMD1 (copper metabolism domain containing 1) is a protein-coding gene located on chromosome 2.
COMM domain-containing protein 1 is a protein encoded by the COMMD1 gene in humans. It was originally known as Murr1 before being differentiated and renamed by Dr. Ezra Burstein's Lab.
COMMD1 is a scaffold protein involved in a variety of cellular processes, many of which are linked to its ability to regulate the ubiquitination of specific proteins. It can modulate the activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, promoting CRL E3 activity, and dissociating CAND1 from CUL1 and CUL2. COMMD1 also promotes the ubiquitination of NF-kappa-B subunit RELA, leading to its proteasomal degradation and downregulation of NF-kappa-B activity. It plays a role in regulating the membrane expression and ubiquitination of SLC12A2, modulating sodium transport in epithelial cells. COMMD1 promotes the localization of SCNN1D to recycling endosomes and promotes CFTR cell surface expression through regulation of its ubiquitination. It also downregulates SOD1 activity by interfering with its homodimerization. COMMD1 is involved in copper ion homeostasis, facilitating copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery. It can bind one copper ion per monomer and may function to facilitate biliary copper excretion within hepatocytes. COMMD1 binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and is involved in regulating HIF1A-mediated transcription. It negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation.
COMMD1 is also known as C2orf5, MURR1.
