CNTROB

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Description

The CNTROB (centrobin, centriole duplication and spindle assembly protein) is a protein-coding gene located on chromosome 17.

CNTROB encodes a protein found in humans that is associated with centrioles. It localizes specifically to the daughter centriole and is vital for both centriole duplication and the process of cell division called cytokinesis.

CNTROB is essential for centriole duplication. Disrupting this process leads to problems with cytokinesis, the division of the cell's cytoplasm.

CNTROB is also known as LIP8, PP1221.

Associated Diseases

• refractive error
• partial chromosome Y deletion
• male infertility with teratozoospermia due to single gene mutation
• spermatogenic failure 3
• spermatogenic failure 26
• spermatogenic failure 31
• spermatogenic failure 52
• spermatogenic failure 23
• spermatogenic failure 61
• spermatogenic failure 74
• spermatogenic failure 73
• spermatogenic failure 5
• spermatogenic failure 29
• male infertility due to globozoospermia
• spermatogenic failure 1
• spermatogenic failure 22