CNTN6
Description
The CNTN6 (contactin 6) is a protein-coding gene located on chromosome 3.
Contactin 6 is a protein found in humans encoded by the CNTN6 gene. It belongs to the immunoglobulin superfamily and is attached to the neuronal membrane through a glycosylphosphatidylinositol (GPI) anchor. This protein acts as a cell adhesion molecule, likely playing a crucial role in the formation of connections between nerve cells during development.
Contactins, like CNTN6, play a crucial role in cell interactions during nervous system development. CNTN6 specifically contributes to the production of oligodendrocytes by acting as a binding partner for NOTCH1. This interaction triggers the activation of NOTCH1, releasing the notch intracellular domain (NICD), which then translocates to the nucleus. This process is essential for proper development. Furthermore, CNTN6 is implicated in motor coordination.
CNTN6 is also known as NB3.
