CNKSR2
Description
The CNKSR2 (connector enhancer of kinase suppressor of Ras 2) is a protein-coding gene located on chromosome X.
CNKSR2 (Connector enhancer of kinase suppressor of ras 2), also known as CNK homolog protein 2 (CNK2) or MAGUIN (membrane-associated guanylate kinase-interacting protein), is an enzyme encoded by the CNKSR2 gene. It acts as a scaffold protein mediating the mitogen-activated protein kinase pathways downstream from Ras. This protein is induced by vitamin D and inhibits apoptosis in some cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. CNKSR2 is the mammalian homolog of the Drosophila gene Cnk, known to bind Raf and implicated in ras signaling. CNKSR2 is also a Raf binding protein, and is assumed to function in bringing together the Ras signaling complex at the post synaptic density. It has two isoforms, one of which binds PSD95 and S-SCAM (synaptic scaffolding molecule) through its PDZ domain, and another which does not. Both isoforms are synaptically localized, mediated by the Pleckstrin homology domain. Its synaptic localization is not affected by NMDA receptor activation. Overexpression of MAGUIN's C-terminal PDZ domain represses synaptic localization of PSD95.
CNKSR2 may act as an adapter protein or regulator within the Ras signaling pathways.
CNKSR2 is also known as CNK2, KSR2, MAGUIN, MRXSHG.
Associated Diseases
- Mental retardation, X-linked, syndromic, Houge type
- Non-specific early-onset epileptic encephalopathy
