CNIH2
Description
The CNIH2 (cornichon family AMPA receptor auxiliary protein 2) is a protein-coding gene located on chromosome 11.
CNIH2 plays a crucial role in regulating the activity of AMPA receptors (AMPARs), a type of glutamate receptor involved in synaptic transmission. It influences how these receptors move within the cell, ensuring they are properly positioned at the synapse. CNIH2 also fine-tunes the way AMPARs respond to glutamate, controlling their activation, deactivation, and desensitization rates. Importantly, it prevents the rapid reactivation of AMPARs by blocking the action of another protein, CACNG8.
CNIH2 is also known as CNIH-2, Cnil.
