CNGA4
Description
The CNGA4 (cyclic nucleotide gated channel subunit alpha 4) is a protein-coding gene located on chromosome 11.
CNGA4 (Cyclic nucleotide-gated cation channel alpha-4) is a protein encoded by the CNGA4 gene in humans. It serves as a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that are responsible for the transmission of odorant signals.
CNGA4 is a modulatory subunit of the cation-selective cyclic nucleotide-gated (CNG) channels that are responsible for the depolarization of olfactory sensory neurons (OSNs). It plays a crucial role in the transduction of odorant signals and the subsequent adaptation. By facilitating calcium-mediated negative feedback in olfactory signaling, CNGA4 allows for rapid adaptation to odor stimulation, thereby extending the range of odor detection.
CNGA4 is also known as CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb.
