CLSPN
Description
The CLSPN (claspin) is a protein-coding gene located on chromosome 1.
Claspin is a protein encoded by the CLSPN gene in humans. Its function in humans is not fully understood, but it is known to be homologous to Xenopus claspin, which plays a crucial role in regulating checkpoint kinase 1 and inducing cell cycle arrest in response to DNA replication issues. CLSPN interacts with several proteins, including BRCA1, CHEK1, ATR, RAD9A, TIMELESS, MCM2-7 complex, CDC7, and PCNA.
CLSPN plays a crucial role in halting the cell cycle in response to disruptions in DNA replication or damage caused by ionizing or UV radiation. It acts as an adapter protein connecting BRCA1 and CHEK1, facilitating their phosphorylation by ATR. Moreover, CLSPN ensures proper replication fork progression during normal DNA replication. It binds directly to DNA, especially branched or forked molecules, and interacts with replisome components like MCM2-7 and TIMELESS. Furthermore, CLSPN is essential for initiating DNA replication by recruiting CDC7 kinase to phosphorylate MCM2-7 components.
CLSPN is also known as -.
