CLK2
Description
The CLK2 (CDC like kinase 2) is a protein-coding gene located on chromosome 1.
CLK2 is a human gene that encodes a dual specificity protein kinase belonging to the CLK family. These kinases interact with and phosphorylate serine/arginine-rich (SR) proteins within the spliceosomal complex, which are essential for regulating RNA splicing. CLK2 plays a role in various cellular processes and may link cell cycle progression, apoptosis, and telomere length regulation.
CLK2 is a dual specificity kinase that phosphorylates both serine/threonine and tyrosine residues. It is involved in the phosphorylation of serine- and arginine-rich (SR) proteins within the spliceosomal complex. This phosphorylation plays a role in regulating RNA splicing by enabling SR proteins to control this process and may cause their redistribution from speckles to a diffuse nucleoplasmic distribution. CLK2 also acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing the transcriptional activity of PPARGC1A on gluconeogenic genes through phosphorylation. Furthermore, it phosphorylates PPP2R5B, stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex, leading to the dephosphorylation of AKT1. CLK2 also phosphorylates PTPN1, SRSF1, and SRSF3. It regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and phosphorylates PAGE4 at multiple serine and threonine residues, attenuating PAGE4's ability to potentiate the transcriptional activator activity of JUN. (PubMed:28289210)
CLK2 is also known as -.
Associated Diseases
- Parkinson disease
- lysosomal storage disease
- Alzheimer disease
- multiple sclerosis
- type 2 diabetes mellitus
- schizophrenia 15
- Phelan-McDermid syndrome
- cancer
- lung cancer
