CLIC1
Description
The CLIC1 (chloride intracellular channel 1) is a protein-coding gene located on chromosome 6.
CLIC1 (Chloride intracellular channel protein 1) is a protein that regulates essential cellular processes like cell membrane potential stabilization, nutrient transport, internal pH maintenance, and cell volume control. It belongs to the p64 family and is primarily located in the cell nucleus. CLIC1 has both nuclear and plasma membrane chloride ion channel activity. It has been shown to interact with TRAPPC2.
CLIC1 can embed itself into cell membranes and create channels that allow chloride ions to pass through. The channel's activity is influenced by the acidity (pH) of the environment. This membrane insertion process appears to be controlled by the balance of oxidation and reduction (redox) within the cell, potentially occurring only under oxidizing conditions. CLIC1 plays a role in regulating the cell cycle.
CLIC1 is also known as CL1C1, CLCNL1, G6, NCC27.
Associated Diseases
- Mobius syndrome
- Glanzmann thrombasthenia 1
- breast cancer
- nonpapillary renal cell carcinoma
- thrombocytopenia 7
- beta-thalassemia-X-linked thrombocytopenia syndrome
- bleeding disorder, platelet-type, 24
- Bernard-Soulier syndrome
- autosomal dominant macrothrombocytopenia
