CLEC1B
Description
The CLEC1B (C-type lectin domain family 1 member B) is a protein-coding gene located on chromosome 12.
CLEC1B (C-type lectin domain family 1 member B) is a protein encoded by the CLEC1B gene in humans. It functions as a receptor expressed on both myeloid cells and natural killer (NK) cells. CLEC1B is involved in various cellular processes, including platelet activation, immune response, and viral attachment. It interacts with other proteins such as SYK, RACK1, and PDPN, playing a role in signaling pathways and cellular regulation.
CLEC1B acts as a platelet receptor for the lymphatic endothelial marker PDPN, triggering a signaling cascade that involves the activation of SRC and SYK tyrosine kinases, ultimately leading to the activation of PLCG2.
CLEC1B is also known as 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721.
Associated Diseases
- thrombocytopenia 7
- bleeding disorder, platelet-type, 24
- Glanzmann thrombasthenia 1
- beta-thalassemia-X-linked thrombocytopenia syndrome
- platelet-type bleeding disorder 15
- Bernard-Soulier syndrome
- platelet-type bleeding disorder 19
- alpha-thalassemia-myelodysplastic syndrome
- hemoglobin D disease
