CLEC16A
Description
The CLEC16A (C-type lectin domain containing 16A) is a protein-coding gene located on chromosome 16.
CLEC16A, encoded by the CLEC16A gene, is a protein found in humans. While its exact function is not fully understood, it is known to be highly expressed in B-lymphocytes, natural killer (NK) cells, and dendritic cells. Despite its name, CLEC16A may not act as a lectin due to the short length of its C-type lectin domain. Notably, variations in the CLEC16A gene have been linked to an increased risk of conditions such as multiple sclerosis and type I diabetes.
CLEC16A plays a crucial role in regulating mitophagy, a process essential for maintaining healthy mitochondria. It does this by controlling the RNF41/NRDP1-PRKN pathway, which is involved in the fusion of autophagosomes with lysosomes during late mitophagy. CLEC16A may also safeguard RNF41/NRDP1 from degradation, allowing RNF41/NRDP1 to regulate the breakdown of PRKN. Importantly, CLEC16A's influence on mitophagy and mitochondrial health is vital for the proper functioning of beta cells.
CLEC16A is also known as Gop-1, KIAA0350.
Associated Diseases
- type 1 diabetes mellitus
- asthma
- systemic lupus erythematosus
- multiple sclerosis
- allergic disease
- childhood onset asthma
- type 2 diabetes mellitus
