CLDN4
Description
The CLDN4 (claudin 4) is a protein-coding gene located on chromosome 7.
Claudin 4, also known as CLDN4, is a protein encoded by the CLDN4 gene in humans. It is a member of the claudin family and is an integral membrane protein that forms part of tight junction strands. CLDN4 may play a role in the development and function of internal organs during prenatal and postnatal life. Its deletion is associated with Williams-Beuren syndrome, a neurodevelopmental disorder. CLDN4 can be used as a marker to distinguish between malignant mesothelioma and lung cancer, as well as uterine serous carcinoma. It is also a superior marker to BerEp4 for detecting pancreatic cancer in cell-blocks of effusion specimens.
CLDN4 is a channel-forming tight junction protein that facilitates the paracellular transport of chloride in the kidney. It plays a key role in the reabsorption of filtered chloride in the collecting ducts of the kidney. Claudins are crucial for the formation of tight junctions, which seal the intercellular space between cells, through their calcium-independent cell-adhesion activity.
CLDN4 is also known as CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R.
