CLDN17
Description
The CLDN17 (claudin 17) is a protein-coding gene located on chromosome 21.
Claudin-17 is a protein encoded by the CLDN17 gene in humans. It belongs to the claudin family, a group of proteins responsible for maintaining cell-cell junctions and tissue barriers. Claudin-17 forms anion-selective paracellular channels, primarily localized in the kidney proximal tubules. These channels facilitate the movement of ions across cell junctions. The protein's main function is to contribute to the barrier function of the kidney, ensuring proper filtration and reabsorption of substances.
Claudin-17 forms channels in tight junctions that selectively allow the passage of anions like chloride and bicarbonate, as well as small solutes (smaller than 9 Angstroms in diameter). It plays a role in the reabsorption of filtered anions in the kidney proximal tubule, but does not influence water permeability.
CLDN17 is also known as -.
Associated Diseases
- endometrial cancer
- substance abuse
- familial idiopathic steroid-resistant nephrotic syndrome
- nephrogenic diabetes insipidus
- diabetes insipidus, nephrogenic, autosomal
- congenital nephrotic syndrome, Finnish type
- nephronophthisis
- Dent disease
- proximal renal tubular acidosis
- juvenile nephropathic cystinosis
- glucose-galactose malabsorption
