CLDN15
Description
The CLDN15 (claudin 15) is a protein-coding gene located on chromosome 7.
Claudin-15 is a protein encoded by the CLDN15 gene in humans. It belongs to the claudin family of proteins, which are involved in forming tight junctions between cells. Tight junctions are important for maintaining the barrier function of epithelial tissues. CLDN15 is particularly involved in the blood-brain barrier, immune cell transmigration, and tight junction signaling pathways. It is known to bind to other proteins and has a structural role. A closely related protein is CLDN10.
Claudins, including CLDN15, are essential components of tight junctions that control epithelial permeability. While some claudins act as impermeable barriers, others, like CLDN15, facilitate the passage of ions and small molecules. The specific permeability profile of an epithelium is determined by the combination of claudins expressed and their interactions. CLDN15 forms tight junctions that selectively allow the movement of small monovalent cations like sodium (Na+), lithium (Li+), and potassium (K+) along their concentration gradient, while blocking chloride (Cl-) ions. This selective permeability is crucial for paracellular Na+ transport in the intestine, contributing to nutrient uptake and overall sodium homeostasis.
CLDN15 is also known as -.
Associated Diseases
- endometrial cancer
- microvillus inclusion disease
- atresia of small intestine
- annular pancreas
- bile acid malabsorption, primary, 1
- congenital short bowel syndrome
- inflammatory bowel disease 30
- deafness-small bowel diverticulosis-neuropathy syndrome
- congenital diarrhea 7 with exudative enteropathy
- chronic diarrhea due to glucoamylase deficiency
- multiple intestinal atresia
