CLCA2
Description
The CLCA2 (chloride channel accessory 2) is a protein-coding gene located on chromosome 1.
CLCA2, or Chloride channel accessory 2, is a protein encoded by the CLCA2 gene in humans. It belongs to the calcium-sensitive chloride conductance protein family and shares similarities in size, sequence, and structure with other family members. While it exhibits a high degree of homology with other members, its distribution in tissues is unique. CLCA2 is primarily found in the trachea and lungs, suggesting a role in the complex pathogenesis of cystic fibrosis. Additionally, it has been proposed to function as an adhesion molecule for lung metastatic cancer cells, facilitating their attachment to blood vessels and colonization. Further research indicates that CLCA2 may act as a tumor suppressor gene for breast cancer. Structural predictions suggest that the N-terminal region of CLCA2 possesses zinc metalloprotease activity.
CLCA2 plays a crucial role in regulating chloride ion flow across the cell membrane, a process that is dependent on calcium levels. It is also involved in cell adhesion, particularly in the formation of basal cell layers and the layering of squamous epithelial tissues. Furthermore, research suggests that CLCA2 may act as a tumor suppressor in breast and colorectal cancers. Importantly, CLCA2 contributes significantly to the initial stages of lung metastasis by facilitating cell adhesion through its interaction with the ITGB4 protein.
CLCA2 is also known as CACC, CACC3, CLCRG2, CaCC-3.
