CLASP2
Description
The CLASP2 (cytoplasmic linker associated protein 2) is a protein-coding gene located on chromosome 3.
CLASP2, also known as Cytoplasmic linker associated protein 2, is a protein encoded by the CLASP2 gene in humans. It plays a role in the stabilization of microtubules, a key component of the cytoskeleton.
CLASP2 is a microtubule plus-end tracking protein that stabilizes dynamic microtubules. It plays a role in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) and is essential for the polarization of microtubule arrays in migrating cells towards the leading edge. CLASP2 may enhance the rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated by phosphatidylinositol 3-kinase signaling. CLASP2 also stabilizes microtubules at the kinetochore, which is crucial for the bipolar alignment of chromosomes during mitosis. It acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
CLASP2 is also known as -.
