CLASP1

Description

The CLASP1 (cytoplasmic linker associated protein 1) is a protein-coding gene located on chromosome 2.

CLASP1, also known as Cytoplasmic linker associated protein 1, is a protein encoded by the CLASP1 gene in humans. It belongs to a family of microtubule-associated proteins involved in attaching microtubules to the cell cortex in animals and plants. CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1). In animal cells, CLASP1 regulates microtubule dynamics at the kinetochore and throughout the spindle. CLASP1 controls the interactions of astral microtubules with the cell cortex in mitosis, which is important for the proper positioning and orientation of the spindle.

CLASP1 is a microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. It is involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) and is required for the polarization of cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. CLASP1 may act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. CLASP1 also performs a similar stabilizing function at the kinetochore, which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

CLASP1 is also known as MAST1.

Associated Diseases

WES Whole Exome Sequencing