CKS1B
Description
The CKS1B (CDC28 protein kinase regulatory subunit 1B) is a protein-coding gene located on chromosome 1.
CKS1B is a protein that plays a crucial role in the regulation of cell cycle progression. It binds to the catalytic subunit of cyclin-dependent kinases, which are essential enzymes for cell cycle control. CKS1B expression varies throughout the cell cycle, suggesting a specialized function. CKS1B interacts with other proteins like CKS2 to regulate cell cycle progression. They act as suppressors of mutations in both fission and budding yeast Cdk1 genes. These interactions are crucial for the assembly of Cdk-dependent enzyme complexes that control the entry of cells into mitosis. Notably, CKS1B also participates in a Cdk-independent pathway where it recognizes substrates p27Kip1 and p21cip1, interacting with E3 SCFSkp2 in response to mitogenic signals like TGF-β. Deficiency in CKS1B leads to slower cell growth and accumulation in the G(2)-M phase due to blocked mitotic entry. This suggests a critical role for CKS1B in regulating cell cycle transitions and overall cell proliferation.
CKS1B is also known as CKS1, PNAS-16, PNAS-18, ckshs1.
