CKMT1B

Description

The CKMT1B (creatine kinase, mitochondrial 1B) is a protein-coding gene located on chromosome 15.

CKMT1B is one of two genes encoding the ubiquitous mitochondrial creatine kinase (ubiquitous mtCK or CKMT1). It plays a critical role in energy transfer within cells, transferring high energy phosphate from mitochondria to the cytosolic carrier, creatine. This gene encodes two isoenzymes: sarcomeric MtCK (CKMT2) and ubiquitous MtCK. CKMT1B exists in two oligomeric forms: dimers and octamers, unlike the exclusively dimeric cytosolic creatine kinase isoenzymes. It shares 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 (CKMT1A and CKMT1B) encode identical mitochondrial creatine kinase proteins. Overexpression of ubiquitous mitochondrial creatine kinase has been observed in many malignant cancers with poor prognosis, potentially due to high energy turnover and resistance to apoptosis.

CKMT1B, also known as ubiquitous mitochondrial creatine kinase, plays a crucial role in energy transfer within cells, particularly in tissues with high energy demands like muscle, heart, brain, and sperm. It acts as a catalyst for the reversible transfer of phosphate between ATP (adenosine triphosphate) and phosphogens, such as creatine phosphate, facilitating the efficient utilization of energy within these tissues.

CKMT1B is also known as CKMT, CKMT1, UMTCK.

Associated Diseases

WES Whole Exome Sequencing