CKMT1A
Description
The CKMT1A (creatine kinase, mitochondrial 1A) is a protein-coding gene located on chromosome 15.
CKMT1A, also known as ubiquitous mitochondrial creatine kinase (uMtCK), is a gene that encodes for a mitochondrial enzyme involved in energy metabolism. It catalyzes the reversible transfer of a phosphate group from ATP to creatine, producing ADP and creatine phosphate. CKMT1A plays a crucial role in energy production within cells. Its impairment has been linked to conditions such as ischemia, cardiomyopathy, and neurodegenerative disorders. Conversely, overexpression of CKMT1A has been associated with various tumors. The CKMT1A gene is located on chromosome 15q15.3 and comprises 11 exons. The protein encoded by CKMT1A consists of 417 amino acids and has a molecular weight of 47037 Da. It is rich in amino acids with hydroxyl-containing and basic side chains. CKMT1A is found in the mitochondrial intermembrane space and forms both homodimeric and homooctameric molecules, which readily interconvert. CKMT1A is ubiquitously expressed and shares the same catalytic activity as other creatine kinase isoenzymes.
CKMT1A catalyzes the reversible transfer of phosphate between ATP and various phosphogens, such as creatine phosphate. This process plays a vital role in energy transduction within tissues that experience significant and fluctuating energy demands, including skeletal muscle, heart, brain, and spermatozoa.
CKMT1A is also known as CKMT1, U-MtCK, mia-CK.
