CKAP5
Description
The CKAP5 (cytoskeleton associated protein 5) is a protein-coding gene located on chromosome 11.
Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is the homolog of the Xenopus protein XMAP215 and is also known as ch-Tog. It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity. CKAP5 has been shown to interact with TACC1.
CKAP5 binds to the plus end of microtubules and regulates microtubule dynamics and organization. It acts as a processive microtubule polymerase, promoting cytoplasmic microtubule nucleation and elongation. CKAP5 plays a key role in organizing spindle poles, protecting kinetochore microtubules from depolymerization by KIF2C during spindle formation, and contributing to centrosomal microtubule assembly independently of KIF2C activity. It also contributes to centrosome integrity. CKAP5 is a component of the TACC3/ch-TOG/clathrin complex, which stabilizes kinetochore fibers of the mitotic spindle by acting as an inter-microtubule bridge. This complex is required for the maintenance of kinetochore fiber tension and enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments.
CKAP5 is also known as CHTOG, MSPS, TOG, TOGp, ch-TOG.
Associated Diseases
- ovarian cancer
- low grade glioma
- congenital prothrombin deficiency
- prothrombin deficiency
- thrombophilia due to thrombin defect
- prostate cancer
- schizophrenia
- cleft palate-lateral synechia syndrome
- cor pulmonale
- X-linked retinal dysplasia
- van der Woude syndrome
- breast cancer
