CKAP4
Description
The CKAP4 (cytoskeleton associated protein 4) is a protein-coding gene located on chromosome 12.
CKAP4 (Cytoskeleton-associated protein 4) is a protein encoded by the CKAP4 gene in humans. It is also known as CLIMP-63 (cytoskeleton-linking membrane protein 63) or p63. This protein is a type II transmembrane protein found primarily in the endoplasmic reticulum (ER) of eukaryotic cells. CKAP4 was discovered in the early 1990s and is known for its role in ER shaping and organization. It forms dimers through its luminal COILED-COIL domains, contributing to the formation of ER sheets. CKAP4's cellular distribution has been studied extensively, and it has been found to have additional functions beyond ER localization. It has been identified as a ligand-activated receptor at the plasma membrane and as a marker in certain cancers.
CKAP4 mediates the anchoring of the endoplasmic reticulum to microtubules.
CKAP4 is also known as CLIMP-63, CLIMP63, ERGIC-63, p63.
